Agglomerations and Granulation for Tableting

By: Gary Wada on Apr 28, 2015

Agglomeration does many things for tablets. The first is it improves the flowability of the blend to be tableted. The better it flows, the more uniform the weight from tablet to tablet will be. Agglomeration can also improve the uniformity of the active ingredients you are looking to deliver in each tablet. In a multi component blend, segregation could be taking place as the blend is transferred.

Through agglomeration, the blend can be “stuck” together in a uniform manner, such as in a fluid bedVitamin Tablets granulator. Proper sizing of the materials before agglomeration should be considered to obtain the most uniform granulation. Low dose actives can have their uniformity increased greatly, by using a fluid bed to spray the active onto a carrier, thus uniformly diluting the active.

Fluid bed granulations are known for their porosity and ability to dissolve by wicking the liquid through its interstitial void space, and dissolving from the inside out. High shear granulations, and chilsonated granules are known for dissolving by erosion only. Even after compression, the fluid bed granules still dissolve faster that those made by high shear or chilsonation. Fluid bed granulation prior to tableting can lower compression force during tableting, reduce the friability of the tablets, and reduce punch wear. Granulation can also reduce dustiness and static problems, and provide a better working environment for the tablet operators.

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