Published on Apr 30, 2015
Instantizing is a subset of agglomeration for the specific purpose of helping powders to mix better with a liquid. Smaller particles can tend to float on top of a liquid and not break the surface tension. By agglomerating, we are making the particles larger, and cause them not to float, but submerge into the water. Fluid bed processing can generate very porous granules, where the water wicks into their insides, causing them to sink and eventually dissolve.
Published on Apr 28, 2015
Agglomeration does many things for tablets. The first is it improves the flowability of the blend to be tableted. The better it flows, the more uniform the weight from tablet to tablet will be. Agglomeration can also improve the uniformity of the active ingredients you are looking to deliver in each tablet. In a multi component blend, segregation could be taking place as the blend is transferred.
Published on Apr 21, 2015
In regards to particle size reduction, there are lots of things you can do with milling and micronizing. You can eliminate stratification problems in fortification and enrichment blends, and in nutrient premixes, by making sure your particles are compatible with each other. Reducing particle size can also be helpful in increasing surface area, which can be a positive or negative thing.